• Another interesting finding from the present study

  2021-03-01

  

  Another interesting finding from the present study is that silencing of ERRγ suppressed the expression of HSD17B1 in extravillous trophoblasts. HSD17B1 is a key enzyme in regulating estrogen activity and has been shown to promote the proliferation and migration of estrogen-dependent breast cancer Di

• Curcumin is found safe in several human studies Chainani

  2021-03-01

  

  Curcumin is found safe in several human studies (Chainani-Wu, 2003; Cheng et al., 2001; Dcodhar et al., 2013), in contrary, the toxicity of curcumin has also been reported under some specific conditions (Burgos-Morón et al., 2010). Moreover, it Fmoc-Cys(Trt)-ol receptor was also reported that curcu

• Recent studies have reported that miR plays an

  2021-03-01

  

  Recent studies have reported that miR-454 plays an important role in various cellular processes and diseases, such as inflammation, infection, osteogenic differentiation, and cancers [25,27,29,30]. Multiple evidence has documented that miR-454 promotes the proliferation, migration and invasion, and

• The role of ETB clearing receptors

  2021-03-01

  

  The role of ETB clearing receptors has been studied in detail in endothelial cell–specific ETB knock-out mice. In these animals, clearance of an intravenous Alda 1 mg of labeled ET-1 was reduced significantly compared with wild-type controls. Importantly, functioning ETB were retained on all other c

• br Acknowledgements br Introduction Three

  2021-03-01

  

  Acknowledgements Introduction Three structurally related fungal metabolites have been isolated from chloroform extracts of submerged rice cultures of Aspergillus terreus 23-1 from stored unhulled rice in Taiwan; these were named territrems A–C to indicate their biological origin (A. terreus) a

• CXCR is not only critical in the

  2021-03-01

  

  CXCR5 is not only critical in the B cell lineage in FL. A high proportion of CXCR5-expressing follicular helper T cells (TFH) were observed in FL but not in closely related DLBCL [141] and further investigation revealed that FL regulatory T cells (Tregs) used a CXCL13-CXCR5 autocrine loop for positi

• One of the hallmarks of the terminal

  2021-02-27

  

  One of the hallmarks of the terminal stages of apoptosis is the fragmentation of chromosomal DNA that proceeds in a two-step manner: the DNA is initially cleaved into 50–300kb fragments and eventually into oligonucleosomal pieces [12], [13]. The two major apoptotic nucleases are DNA fragmentation fa

• NCT-502 Oral antipsychotics are substrates of CYP

  2021-02-27

  

  Oral antipsychotics are substrates of CYP450 enzymes, which are crucial to their metabolism and elimination (Fig. 1). The efficacy and toxicity of antipsychotic agents is affected by factors that induce or inhibit CYP450 expression and function, such as drug–drug interactions. Additionally, the mult

• In conclusion the magnitude of the association

  2021-02-27

  

  In conclusion, the magnitude of the association between prenatal exposure to MeHg and child neuropsychological development appears to be modified by polymorphisms in CYP3A7 and CYP3A5 genes in some of the populations studied. These results provide some support for the hypothesis that CYP3A genes may

• br Genotype phenotype correlations Genotype phenotype correl

  2021-02-27

  

  Genotype-phenotype correlations Genotype-phenotype correlations are limited. Compared with individuals with truncating variants, those with pathogenic missense variants in the adenosine triphosphate binding site had a milder disorder, some with ability to walk unaided, better hand use, and less r

• Since its inception ADEPT approach

  2021-02-27

  

  Since its inception, ADEPT approach has been widely reported by many groups using a variety of enzymes and prodrugs (see reviews) [12], [14]. Both mammalian and non-mammalian enzymes have been utilised. Of the mammalian variety, human β-glucuronidase in combination with many prodrugs [17], [18] and

• The estrogenic activity of steroids with a C methyl

  2021-02-27

  

  The estrogenic activity of steroids with a C19 methyl group may provide a selective advantage in estrogen physiology that is not provided by E2. In this regard, 5α-androstanediol has been proposed to be a second physiological estrogen in fetal mouse BX-912 based on the timing of ERβ synthesis in mou

• br Enzyme catalysis A biochemically

  2021-02-27

  

  Enzyme catalysis A biochemically spontaneous process proceeds in a direction where free comt inhibitor of the system decreases. However, every spontaneous or energetically favorable reaction needs to overcome an energy barrier known as the activation energy barrier because of the formation of an

• Immunomodulation effects of certain oxysterols were previous

  2021-02-27

  

  Immunomodulation effects of certain oxysterols were previously shown to depend on activation of oxysterol-binding liver X receptors (LXRs). Recent work from our labs as well as from others has shown additional receptors linking oxysterols and immunity. For example, we found that 7α,25-dihydroxychol

• The Inhibitor of APoptosis IAP

  2021-02-27

  

  The Inhibitor of APoptosis (IAP) proteins were first identified as gene products of baculovirus that inhibited apoptosis of infected insect Z-DEVD-AFC (Clem et al., 1991, Crook et al., 1993). Subsequently, the mammalian IAP family was identified (Rothe et al., 1995, Uren et al., 1996). All members

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