• Clinical practice guidelines are written under the auspices

  2020-08-04

  

  Clinical practice guidelines are written under the auspices of national or international societies, such as the American College of Cardiology (ACC), the American Heart Association (AHA), and the European Society of Cardiology (ESC), to provide physicians with practical recommendations for the best

• br Covalent reversible post translational modification of ce

  2020-08-04

  

  Covalent, reversible, post-translational modification of cellular proteins with the small modifier, ubiquitin (Ub), regulates virtually every known cellular process in eukaryotes. A protein may be modified with a single Ub (mono-ubiquitination), several single Ubs, or multiple Ubs that are covalen

• AEB071 receptor Oysters belong to the second largest animal

  2020-08-04

  

  Oysters belong to the second largest animal phylum Mollusca, and they are globally distributed aquaculture animals (Wang et al., 2018). A number of studies have demonstrated that oysters have evolved an integrated and complex innate AEB071 receptor to recognize and eliminate various invaders. An arr

• A significant issue that has limited the

  2020-08-04

  

  A significant issue that has limited the biochemical characterization of the E1 helicase to only a few PV types has been the difficulty in expressing and purifying large quantities of the protein in a recombinant form that can support cell-free DNA replication. This is in part due to the fact that E

• DGKs have been identified in unicellular organisms such as b

  2020-08-04

  

  DGKs have been identified in unicellular organisms such as bacteria, but these DGKs are structurally different from those identified in higher eukaryotes such as Drosophila melanogaster[5], [6], [7], Arabidopsis thaliana[8], [9], Caenorhabditis elegans[10], [11], and mammals [12]. For example, bacte

• br Amygdala microcircuitry and fear learning

  2020-08-03

  

  Amygdala microcircuitry and fear learning Recent work has begun to dissect functional amygdala circuits that are responsible for the acquisition and expression of fear learning. Ciocchi et al. (2010) identified separable populations of adenosine diphosphate within the CeAL that have opposite res

• Social memory is encoded within certain sites but meaning de

  2020-08-03

  

  Social memory is encoded within certain sites, but meaning depends upon an interpretant (such as a tourist) being able to decode the signs. Memorials, such as cemeteries, require some kind of activity by its visitors for their meanings to be activated (Hutchinson, 2009, Winter, 2010). Following Eden

• In the present work we have investigated the reactivity of

  2020-08-03

  

  In the present work, we have investigated the reactivity of N-aryl-N′-hydroxyguanidines 1a–d (see Scheme 1 for structures) with the water-soluble Cu(II) complex 8. Using EPR and UV–Visible spectroscopy, we have shown that the studied N-aryl-N′-hydroxyguanidines 1a–d can bind and transfer electrons t

• A number of chemical strategies have been developed

  2020-08-03

  

  A number of chemical strategies have been developed to design activatable optical imaging probes and have been summarized in several excellent reviews 11., 12., 13., 14., 15.. Fluorogenic enzyme substrates are one of the most explored activatable probe types for enzyme detection. These probes contai

• As a co factor CIITA lacks the ability to

  2020-08-03

  

  As a co-factor, CIITA lacks the ability to recognize and directly bind to specific DNA elements to regulate transcription; instead, it relies on interaction with sequence-specific transcription factors (TFs) to be recruited to the chromatin. Therefore, the observation that CIITA binds to a specific

• To our knowledge neither in vivo

  2020-07-31

  

  To our knowledge, neither in vivo nor in vitro inhibitions by potential flavones such as diosmin, naringenin, and naringin on the piscine CYP450 system have been studied. The European Food Safety Authority concluded, based on available information of naringin effects in target organisms, that its pr

• Synthetic progestogens also known as

  2020-07-31

  

  Synthetic progestogens (also known as ‘synthetic gestagens’, ‘synthetic progestins’ or simply ‘progestins’) are designed to mimic the effects of 96365 (P4) and are the active pharmaceutical ingredient in many contraceptives and hormone replacement therapies. Since most progestins are derived from s

• br Author contribution br Author

  2020-07-31

  

  Author contribution Author information Reprints and permission information is available at (https://www.journals.elsevier.com/biochemical-and-biophysical-research-communications). Readers are welcome to comment on the online version of the paper. Correspondence and requests for materials shoul

• The relationship of DDR expression to tumor aggressiveness o

  2020-07-31

  

  The relationship of DDR1 POM 1 to tumor aggressiveness or patient outcome has been investigated for other types of cancer, but these other investigations have typically only considered expression of tDDR1 protein. For example, Quan et al. reported that the DDR1 protein was highly expressed in 69% (

• br Conflicts of interest br Financial support

  2020-07-31

  

  Conflicts of interest Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818

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